Number of the world’s 50 most expensive wines that come from Burgundy, France. According to wine-searcher.com’s annual ranking, the perennial #1 is DOMAINE de la ROMANÉE-CONTI “Romanée-Conti” Grand Cru, with an average price of $19,378 a bottle. After Burgundy, Germany’s Mosel region had the next most wines on the list with 5. Somewhat shockingly, only 3 wines from Bordeaux were among the top 50. And not surprisingly, the 2 Napa Valley wines on the list were both from Screaming Eagle.